Senior Research Associate, Metabolism

About NewLimitNewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.PositionNewLimit is seeking a Senior Research Associate with experience in liver biology or in vivo physiology to join our Metabolism team. Our Metabolism team is developing reprogramming medicines to restore youthful function in aged hepatocytes in the context of metabolic disease. In this role, you will help develop epigenetic editing tools, functional assays, and model systems to measure the effectiveness of our therapeutic candidates.What you'll doCollaborate with our Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test epigenetic reprogramming interventions for aged and diseased hepatocytesPerform experiments in preclinical animal models of liver diseaseConduct functional and phenotypic assays to evaluate the effects of reprogramming on hepatocyte biology in vivoDeliver epigenetic reprogramming perturbations to hepatocytes in vivo using multiple transgenic manipulation methods (e.g. viral vectors, lipid nanoparticles)Isolate murine and human hepatocytes by liver perfusion with downstream FACS analysisRequirementsBS in cell biology, molecular biology, or a related natural science and 2+ years of work experience in a cell biology or animal physiology laboratory (academic or industry setting)Proficiency in animal handling and husbandry techniques for rodent models (mice or rats)Exceptional organizational skills, including detailed experimental record-keeping and the ability to manage multiple concurrent projectsExperience with standard molecular biology techniques, including gel electrophoresis, nucleic acid purification, and PCRNice to haveExperience working with mouse models of aging, disease and liver dysfunctionExperience with in vivo manipulation of hepatocytes and liver perfusion techniquesExperience with single-cell genomics or other functional genomics approachesProficiency in molecular biology and molecular cloning methodsBenefitsNewLimit offers generous benefits to ensure our team can focus on our mission:Health, dental, and vision insurance401(k) with company matchPaid parental leaveIndustry-leading paid time off (PTO) - 20 days/year for all employees + holidaysMeals and snacks on-siteSalary Range: $90,000 to $105,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.

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