Postdoctoral researcher in neurodegenerative disease and cancer

The laboratory of Professor Xiaolu Yang at the Perelman School of Medicine, University of Pennsylvania, is seeking a highly motivated postdoctoral researcher to join our dynamic and interdisciplinary team. Our work investigates the fundamental mechanisms that drive neurodegenerative disease and cancer, with current projects centered around two major research areas: 1. Protein quality control, aging, and neurodegenerative diseases Our laboratory has discovered two previously unrecognized protein quality control (PQC) systems involving tripartite motif (TRIM) proteins and poly-Asp/Glu (polyD/E) proteins. These pathways function independently of ATP and exhibit distinct evolutionary conservation-TRIM in animals and polyD/E across eukaryotes-setting them apart from established PQC mechanisms. Ongoing work aims to define their molecular mechanisms, elucidate their contributions to aging and neurodegenerative diseases (Alzheimer's, Parkinson's, ALS), and explore their potential for therapeutic intervention. 2. Tumor suppression, metabolism, and autophagy We examine the regulatory mechanisms and functional roles of the tumor suppressor p53, with emphasis on its control of metabolic pathways essential for biosynthesis and redox balance. Our studies explore how p53 integrates metabolic cues by acting as both a sensor and regulator of cellular metabolism. In parallel, we are identifying metabolic changes that promote tumor initiation and progression. This work has recently expanded to include investigations into how metabolism and autophagy influence the biology of embryonic and cancer stem cells. For more information about our research, please see the following publications and website: Science 381: eadd6696 (2023) PMID: 37499037 Science Advances 8: eabo0404 (2022) PMID: 35857842 Nature 597: 132-137 (2021) PMID: 34408321 Nature Cell Biology 23: 978-991 (2021) PMID: 34497368 Cell Metabolism 33: 94-109 (2021) PMID: 33159852 Science 369: 397-403 (2020) PMID: 32703873 Cell Reports 33: 108418 (2020) PMID: 33264628 Nature Communications 11: 348 (2020) PMID: 31953436 Nature Communications 10: 1495 (2019) PMID: 30940803 Nature Communications 9: 4683 (2018) PMID: 30409970 Nature Communications 9: 1223 (2018) PMID: 29581427 Cell Reports 18: 3143-3154 (2017) PMID: 28355566 Molecular Cell 55: 15-30 (2014) (Cover Article) PMID: 24882209 Nature 493: 689-93 (2013) PMID: 23334421 Nature Cell Biology 15: 991-1000 (2013) (Cover Article) PMID: 23811687 Nature Cell Biology 13: 310-316 (2011) (Cover Article) PMID: 21336310 Molecular Cell 37: 668-678 (2010) (Cover Article) PMID: 20227371 Lab website: Applicants should hold, or be nearing completion of, a PhD or MD degree and demonstrate a strong publication record, rigorous experimental skills, and relevant experience in areas such as biochemistry, cell biology, molecular biology, metabolism, stem cell biology, neuroscience, cancer research, or animal models. Review of applications will begin immediately and will continue until the position is filled. Applications should be sent through Interfolio using the link below and include: 1. Cover Letter; 2. Curriculum vitae; 3. Contact intormation tor three references. The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state, or local law.

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