Staff Scientist - Analytical Pharmacology Core Facility for Pharmacokinetic (PK), Pharmacodynamic (PD), and Biomarker Studies

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. The Beckman Research Institute of City of Hope is looking for a talented Staff Scientist to perform several functions as a member of the Analytical Pharmacology Core Facility. You will support preclinical and clinical research by generating high-quality bioanalytical data for pharmacokinetic (PK), pharmacodynamic (PD), and biomarker studies. You will be responsible for the development, validation, and application of LC-MS/MS methods to quantify small molecules and related analytes in biological matrices. Working within a service-oriented core facility, you will operate both independently and collaboratively to deliver accurate, reproducible, and regulatory-compliant data. The position emphasizes hands-on operation, maintenance, and troubleshooting of LC-MS/MS instrumentation to ensure reliable performance and data integrity. Although based in an academic setting, the core follows industry-aligned practices, including GxP principles, SOP adherence, and rigorous documentation standards. Success in this role requires strong technical expertise, attention to detail, and the ability to independently resolve analytical and instrument-related challenges. As a successful candidate, you will: * Develop, optimize, validate, and apply LC-MS/MS methods for quantitative analysis of small molecules and biomarkers in biological matrices * Perform routine and non-routine bioanalytical sample analysis in support of PK/PD, toxicology, and translational studies * Independently troubleshoot assay performance, sample preparation, and instrument-related issues to ensure data quality and reproducibility * Operate, maintain, and troubleshoot LC-MS/MS systems and associated LC instrumentation; coordinate routine maintenance and address performance issues as needed * Analyze and interpret bioanalytical data using appropriate software tools and ensure accuracy, consistency, and completeness of results * Maintain clear, thorough, and compliant documentation of experimental procedures, data, and results in accordance with SOPs and applicable regulatory standards * Adhere to GxP principles, institutional policies, and study protocols, as applicable * Communicate results, technical issues, and study progress effectively to investigators and collaborators * Contribute to preparation of technical reports, study summaries, and supporting documentation for research and regulatory purposes * Participate in laboratory investigations, including deviation identification, root cause analysis, and implementation of corrective actions * Support continuous improvement of laboratory workflows, assay robustness, and data quality * Maintain a safe, organized, and compliant laboratory environment Your qualifications should include: * Ph.D. in chemistry, biochemistry, pharmaceutical sciences, or a related field with 0-3 years of relevant experience; OR M.S. with 3-5 years; OR B.S. with 5-8 years of relevant experience * Strong hands-on experience with LC-MS/MS bioanalysis of small molecules * Demonstrated experience in method development, validation, and quantitative analysis in biological matrices * Experience with sample preparation techniques (e.g., protein precipitation, LLE, SPE) * Familiarity with pharmacokinetic/pharmacodynamic studies and bioanalytical workflows * Experience in a CRO, pharmaceutical, or biotech environment * Experience with Waters and/or AB Sciex LC-MS/MS instrumentation is highly desirable * Experience with ICP-MS analysis using Agilent systems is a plus * Proficiency with instrument control and data acquisition software (e.g., MassLynx, Analyst) * Experience with instrument maintenance, troubleshooting, and performance optimization * Strong foundation in analytical chemistry, including principles of quantitative analysis * Familiarity with GxP practices and FDA Bioanalytical Method Validation Guidance for Industry * Strong interpersonal, documentation, and organizational skills, with a demonstrated commitment to delivering high-quality analytical support in a core facility environment City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

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