Director, Scientific Operations

About Glyphic:At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$80M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.What we are looking for in youGlyphic is seeking a scientifically rigorous, pragmatic, and execution-driven leader for a Director of Scientific Operations, reporting to the VP of R&D.The Director of Scientific Operations will own the preparation, stabilization, and management of evaluation-grade reagents and scientific operations that enable reliable execution of our single-molecule protein sequencing platform. This role works closely with the Director of Chemistry and the Director of Assay Development to translate novel chemical components and reagents into stockable, assay-ready units, and to collaboratively understand which reagent attributes are most important for assay performance. This is a hands-on leadership role focused on scientific judgment, speed, and reproducibility in an early-stage R&D environment. Characterization is intentionally fit-for-purpose and evolves alongside assay understanding.The ideal candidate brings strong operational and scientific judgment, clearly distinguishing which reagent attributes matter-and which do not-for assay performance, while building fit-for-purpose operational frameworks that enable chemistry inventions to be translated into usable, reproducible reagents without unnecessary delay or over-characterization.This role offers a unique opportunity to define and lead scientific operations at a formative stage, ensuring reagent knowledge, operational infrastructure, and assay understanding evolve in lockstep to support the company's next-generation protein sequencing platform.This is a full-time, exempt, in-person position with work conducted at our Berkeley, CA location.What you'll doReagent Preparation & StockingPrepare, formulate, stabilize, and stock evaluation-grade reagents and buffers required for sequencing assaysEstablish storage conditions, handling practices, and refresh strategies that preserve assay-relevant performanceDesign and run fit-for-purpose stability studies to understand how reagents change over time and under different conditionsProduce and manage reagent and assay-ready consumable inventories sufficient to support ongoing experiments, demos, and early evaluationsCollaborative Characterization & UnderstandingWork with Chemistry and Assay teams to identify which reagent attributes matter most for assay performance (e.g., purity, activity, labeling efficiency, degradation modes)Perform and coordinate targeted, hypothesis-driven characterization to inform assay interpretation and reagent handlingTranslate experimental observations into practical guidance for reagent preparation, storage, and useAvoid premature or exhaustive characterization that does not inform assay performanceCross-Functional EnablementPartner closely with the Director of Chemistry to understand chemical design intent and expected behaviorPartner closely with the Director of Assay Development to ensure reagents meet assay needs and constraintsTranslate chemistry prototypes into repeatable, reproducible reagent preparation workflowsIdentify sources of reagent variability and drive scientific root-cause analysis in collaboration with chemistry and assay teamsInfrastructure, Facilities & ProcessDevelop lightweight documentation for reagent preparation, stabilization, storage, and usage; translate R&D protocols into fit-for-purpose SOPs as neededBuild and maintain lab infrastructure required for reagent preparation and storageOversee facilities operations as they relate to R&D, serving as the connective tissue between scientific operations and facilitiesNegotiate terms and manage relationships with vendors and service providers; ensure consumables, equipment, lab spaces, and utilities support evolving R&D needsServe as the scientific owner for reagent readiness prior to any future manufacturing transitionEnsure equipment functionality, inventory and supply management, safety compliance, and other logistical functions of a research laboratoryTeam & Lab OperationsLead and mentor a small team (approximately 2 people) supporting reagent preparation and general lab stockingOversee day-to-day lab readiness, including consumables, buffers, and shared reagent availabilityEstablish lightweight processes to keep the lab running smoothly without over-engineeringWhat you needRequired:BS/MS degree in Chemistry, Chemical Biology, Biochemistry, Engineering, or a related discipline7-10+ years of relevant industry experience supporting R&D teams in scientific operationsProven experience managing reagent inventory, forecasting demand, and preventing stock-outs for active R&D programsDeep hands-on experience with reagent preparation, formulation, stabilization, and fit-for-purpose characterization, including translating R&D protocols into usable SOPsFamiliarity with sequencing or broader omics workflows, including custom reagents, consumables, and specialized equipmentDemonstrated people-leadership experience, including supervising staff and reporting forecasts, plans, and risks to managementStrong negotiation skills with external vendors, including securing favorable contract terms, pricing, and supply agreementsExperience collaborating with procurement and accounting functions (e.g., forecasting inputs, hand-offs to AP)Excellent cross-functional communication skills and comfort coordinating across Chemistry, Assay Development, Operations, and FacilitiesNice to have:Demonstrated ability to proactively identify and resolve emerging scientific or operational issues before they impact assay execution or timelinesComfort operating in early-stage environments with minimal structure and evolving prioritiesWe're looking for a teammate that:Navigates complex team dynamics, partnerships, and challenges with creativity and logic.Operates with adaptability, urgency, and flexibility in evolving environments, thriving in ambiguity.Drives work forward without needing to be asked, taking responsibility for outcomes rather than tasks.Treats obstacles as problems to be creatively solved, not reasons something can't be done.Applies sound judgment to the best available information, testing, learning, and iterating.Shares early and directly when assumptions change, results are unclear, or timelines are at risk.What you can expect from this roleWork environment:Collaborative culture where your ideas and expertise are valuedDirect impact on product development and company directionProfessional growth:Opportunity to build and scale a high-impact scientific operations function.Learn from a diverse team of world-class scientists and engineersCompensationEstimated Base Salary $166,050 - $201,925This is the pay range for this position that we reasonably expect to pay. Individual compensation is based on various factors including, experience, education, skillset, and geographic location. This range is for the SF Bay Area, California location and may be adjusted to the labor market in other geographic areas.Benefits and Perks:Employee Stock Option Plan100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)Employer Retirement Contributions to 401(k)Generous Paid Time OffPaid Maternity and Paternity LeaveHealth & Wellbeing ProgramOffice Snacks and BeveragesRegular Team Bonding ActivitiesWe are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Individuals seeking employment at Glyphic Biotechnologies are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.

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