Job Description:

Role SummaryYou could be just the right applicant for this job Read all associated information and make sure to apply.The Senior Medical Director will have clinical development responsibility for advancing the Company's Phase 1/2 study of LX1001 for APOE4-associated Alzheimer's Disease (AD), including serving as medical monitor for the study. The Senior Medical Director will also be responsible for designing future studies of LX1001, as well as the clinical development strategy for next-generation therapies in the Company's pipeline for APOE4-associated AD. Expertise in Alzheimer's Disease and its mechanisms and the ability to evaluate, interpret, and communicate pre-clinical and clinical data are critical aspects of the role.LocationOur work culture is a hybrid model with days in the New York City office and days working from home. We welcome applications from candidates located across the Northeast and Mid-Atlantic. A remote working model may be considered for exceptional candidates.Primary ResponsibilitiesOversee all clinical development and strategy aspects of the LX1001 clinical programDevelop relationships with external experts and advisorsLead protocol development and drafting of protocols and amendmentsOversee conduct of clinical trials including start up, execution, and generation/interpretation of efficacy and safety resultsEnsure clinical support of trials as needed; conduct ongoing medical and scientific review of clinical trial data with cross functional team; manage patient safety reports on trial data to safety and clinical boards; provide input into final analyses and interpretation including the development of the study reports, publications and internal/external presentationsPresent clinical strategy and clinical trial data to management and other internal and external venuesParticipate actively in Regulatory agency interactions, contributing to document generation and participating in meetings with Regulatory agenciesCultivate and maintain strong working relationships with key opinion leaders, scientific advisors, and other external experts and stakeholdersPresent clinical strategy and clinical trial data to Company management and external stakeholders, including data safety monitoring boardsParticipate actively in preparation of regulatory submissions, briefing documents, safety reports, BLAs/MAAs, and other regulatory correspondence, and personally participate in regulatory agency interactionsProvide medical expertise to teams where either general medical expertise is required or where specialty medical input is requiredLiaise with Chief Scientific Officer and CSO Team regarding preclinical and nonclinical activities relevant to corporate pipeline and clinical development strategyPerform other duties as requiredRequired Skills & QualificationsBoard-certified MD with 10+ years of direct clinical experienceSpecialization in Alzheimer's Disease and/or industry experience in CNS drug developmentGene Therapy experience in a biotech company preferredDemonstrated ability to think strategically, work independently and be a problem solverHighly motivated and accountable, self-directed, and able to execute with attention to detailExcellent communication and interpersonal relationship skills including negotiating and relationship management skills across multiple functions and with external stakeholdersSkilled at leading and motivating teams to prioritize tasks and deliver on deadlines in a highly collaborative and collegial work stylePatient-focused with a deep commitment to understanding the needs and improving the lives of patientsEnjoy being part of a growing team and fast-paced environmentAnticipated Salary RangeDepending on qualifications and overall experience, base salary is likely to be $250,000 - $350,000 per year.Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.