Job Description:

Company OverviewSince its inception over a decade ago,CRISPR Therapeuticshas transformed from a research-stage company advancing programs in the field of gene editing, to a company with a diverse portfolio of product candidates across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine, cardiovascular and rare diseases. The Nobel Prize-winning CRISPR science has revolutionized biomedical research and represents a powerful, clinically validated approach with the potential to create a new class of potentially transformative medicines. To accelerate and expand its efforts,CRISPR Therapeuticshas established strategic partnerships with leading companies includingBayerand Vertex Pharmaceuticals.CRISPR Therapeutics AGis headquartered inZug, Switzerland, with its wholly-ownedU.S.subsidiary,CRISPR Therapeutics, Inc., and R&D operations based inBoston, MassachusettsandSan Francisco, California, and business offices inLondon, United KingdomPosition SummaryThe candidate will be leading our efforts in the design and execution of novel and existing lipid nanoparticle (LNP) formulations to help advance our non-viral delivery platform and take next-gen editing modalities for bespoke indications from concept to clinical application. We are searching for a driven, enthusiastic, and self-motivated individual who is comfortable multitasking and working independently as well as part of a larger team on various aspects of in-vivo delivery. This individual will join the dynamic, rapidly growing, and highly collaborative CRISPR-X division.ResponsibilitiesDesign, optimize, and execute LNP formulations for a variety of compositions and payloads with minimal supervisionDetermine key formulation parameters to provide reproducible and effective LNPs.Lead the production and characterization of LNPs for various studies enabling a clinical applications.Work collaboratively with scientists across the organization to advance company goals and enhance the understanding of LNP function.Be highly organized and meticulous in documenting results in electronic lab notebooks, and present findings to the broader team.Effectively multitask and manage multiple projects simultaneously.Stay up to date on in-vivo delivery literature and industrial practice.Minimum QualificationsPh.D. in Bioengineering, Chemical Engineering, Biochemistry, Organic Chemistry, or related field andScientist I: 0-2 years of relevant experienceScientist II: 2-5+ years of relevant experienceExtensive hands-on experience and deep expertise in formulating LNPs for gene editing applications in human health.Hands on experience with HPLC, DLS, Ribogreen, TEM and other analytical methods.Pays great attention to details in the quality and reproducibility of the LNPsStrong communication and troubleshooting skills.A team player with strong interpersonal skills, and ability to collaborate effectively with others.Preferred QualificationsPrior experience in LNP conjugation chemistries for drug deliveryPrior experience in using LNPs in mammalian cell culture and animal petenciesCollaborative - Openness, One TeamUndaunted - Fearless, Can-do attitudeResults Orientation - Delivering progress toward our mission. Sense of urgency in solving problems.Entrepreneurial Spirit - Proactive. Ownership mindset.