Job Description:

Company OverviewSince its inception over a decade ago,CRISPR Therapeuticshas transformed from a research-stage company advancing programs in the field of gene editing, to a company with a diverse portfolio of product candidates across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine, cardiovascular and rare diseases. The Nobel Prize-winning CRISPR science has revolutionized biomedical research and represents a powerful, clinically validated approach with the potential to create a new class of potentially transformative medicines. To accelerate and expand its efforts,CRISPR Therapeuticshas established strategic partnerships with leading companies includingBayerand Vertex Pharmaceuticals.CRISPR Therapeutics AGis headquartered inZug, Switzerland, with its wholly-ownedU.S.subsidiary,CRISPR Therapeutics, Inc., and R&D operations based inBoston, MassachusettsandSan Francisco, California, and business offices inLondon, United Kingdom.Position SummaryCRISPR Therapeutics is seeking a highly passionate, creative, and motivated mRNA scientist to join our In Vivo Technical Operations department in Boston, Massachusetts. The incumbent will be responsible for the mRNA synthesis, purification, formulation, and analysis to support the process development of mRNA production in various scales. This candidate will work cross-functionally with R&D program teams in the early-stage development and provide strategic and technical support as the programs advance into manufacturing stage.ResponsibilitiesImplement and optimize the process for mRNA synthesis, purification, and purification.Characterize mRNA for purity determination and impurity profiling.Manage lab instruments and reagent inventoryMaintenance of an accurate and up-to-date record of experiments and results in the form of ELN entries and written reportsCommunication of key findings in group and cross-functional team meetingsContribution to regulatory and IP filingsPerformance of laboratory work in safe, efficient manner that ensures a safe working environment for all colleaguesMinimum QualificationsPhD degree in Bioengineering, Molecular Biology, Biochemistry, Pharmaceutical Sciences, or related fieldAt least 2 years of experience working in an industry lab with a proven record of developing and executing novel mRNA upstream and downstream process.Strong hands-on skills, organizational skills, and attention to details in laboratory benchworkFundamental knowledge in RNA chemistry, gene editing and non-viral delivery system.A learner's mindset with a commitment to personal growth and a drive to broaden technical skills and scientific knowledge.Willingness to invest in communications and scientific engagements with colleaguesAbility to think strategically, efficiently manage time and workflows, and work both independently and collaboratively in a cross-functional team environment.Preferred QualificationsPrior experience with mRNA upstream and downstream process developmentPrior experience with immortalized or primary cell culture handling and transfection.Working experience with analytical techniques (such as Bioanalyzer, UPLC) and data interpretationWorking experience with python language is petenciesCollaborative - Openness, One TeamUndaunted - Fearless, Can-do attitudeResults Orientation - Delivering progress toward our mission. Sense of urgency in solving problems.Entrepreneurial Spirit - Proactive. Ownership mindset.